Table of Contents
Is salvinorin A an opioid?
Functional studies demonstrated that Salvinorin A is a potent κ opioid agonist at cloned κ opioid receptors expressed in human embryonic kidney-293 cells and at native κ opioid receptors expressed in guinea pig brain.
Where is salvinorin A found?
Salvinorin A is a chemical found in the plant Salvia divinorum that produces powerful out-of-body and amnesia-like experiences over a short time frame similar to the effects of nitrous oxide (“laughing gas”), which is used at dental offices.
Who discovered salvinorin A?
Salvinorin A, the most potent naturally occurring hallucinogen, is found in Salvia divinorum, a rare Mexican plant from the mint family. It was described and named in 1982 by A. Ortega and co-workers. At least 12 similar compounds have been discovered or synthesized, but none are appreciably psychoactive.
How does salvinorin A affect the brain?
Salvinorin A affects structures in the brain called opioid receptors. This makes salvia different from other hallucinogenic drugs like LSD and mushrooms, which affect the brain’s levels of a chemical called serotonin.
Is salvinorin A water soluble?
Solubility. Salvinorin A is soluble in organic solvents such as ethanol and acetone, but not especially so in water.
Is Purple Sage hallucinogenic?
It is a mild hallucinogen when smoked, and is used in Native American ceremonies and Native American herbal medicine. It is native to the western United States, including Utah, and has been identified as the plant Grey had in mind.
How do I protect my salvias over winter?
Salvias vary in their hardiness. Half-hardy perennial salvias can be left in the ground where they have been growing if the soil is not too cold or wet in winter. Cut back the top growth to 15cm and protect the roots and basal buds with a thick layer of manure or bark chippings.
What is salvinorin used for?
Salvinorin A is under preliminary research for its possible use as a scaffold in medicinal chemistry to develop new drugs for treating psychiatric diseases, such as addiction from cocaine dependence.
Does salvia release dopamine?
Salvia alters dopamine levels in ancient parts of the brain responsible for motivation, reward, and the internal sense of what is going on in our bodies.