Table of Contents
What is the route of administration for rimonabant?
Rimonabant
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | A08AX01 (WHO) |
| Legal status | |
| Legal status | Withdrawn from European and Brazilian markets; not approved elsewhere |
What are the side effects of rimonabant?
The side effects reported were mainly mild and transient and most frequently involved nausea, diarrhea, and dizziness. Rimonabant has potential as a treatment for smoking cessation because the central cannaboid system is also involved in the body’s response to tobacco dependence.
What is rimonabant used for?
Rimonabant is a selective central cannaboid (CB1) receptor antagonist. It is an appetite suppressant in advanced development for obesity treatment. The rationale behind this drug is to reduce appetite by blocking cannaboid receptors in the hypothalamus.
Is rimonabant a cannabinoid?
Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in animal and clinical studies.
Why is rimonabant banned?
Indian Health Ministry bans obesity drug rimonabant following reports of side effects; TB drug curb moves ‘a failure’ The drug has been found to create psychiatric side effects including suicidal tendencies and has been banned in several developed countries.
What is the half life of rimonabant?
Similarly, the functional half-life of rimonabant was 118.9 (±66.1-213.9) min in EXP-2.
Is rimonabant FDA approved?
FDA Advisory Committee did not recommend approval of rimonabant (Zimulti®) for use in obese and overweight patients with associated risks factors.
How long does sibutramine stay in your system?
Sibutramine is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically-active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively.
Is Rimonabant FDA approved?
Is rimonabant banned?
Indian Health Ministry bans obesity drug rimonabant following reports of side effects; TB drug curb moves ‘a failure’
What kind of effect does rimonabant have on the body?
Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite.
When to use rimonabant as an adjunct to diet?
As an adjunct to diet and exercise for the treatment of obese patients (BMI 30 kg/m2), or overweight patients (BMI 27 kg/m2) with associated risk factor (s), such as type 2 diabetes or dyslipidaemia (see section 5.1).
When was rimonabant approved for use in Europe?
Rimonabant is a selective CB1 receptor blocker and was discovered and developed by Sanofi-Aventis; On 21 June 2006, the European Commission approved the sale of rimonabant in the then-25-member European Union as a prescription drug for use in conjunction with diet and exercise for patients with a body mass index (BMI)…
When is the best time to take rimonabant?
It comes as a tablet to take by mouth, before breakfast. What are the warnings and precautions for Rimonabant? • Caution should be exercised in patients with history of liver or kidney impairment, epilepsy, who are taking other medications, any allergy, during pregnancy and breastfeeding.