Table of Contents
Which are anticancer agents?
Anticancer agents can also be classified by indication (lymphoma, leukemia, melanoma, solid tumor), mechanism of action (such as alkylating agents, antibiotics, biological response modifiers, antiandrogens, topoisomerase inhibitors or protein kinase inhibitors), chemical structure (folic acid analog, platinum …
Which is source of an anticancer drug?
Not only the marines represent the main source for anticancer drugs but also there are other vital sources like as plants, animals, invertebrates and terrestrial microbes, for example Taxol; is an antineoplastic drug obtained from the bark of the Western Yew tree (Taxus brevifolia L., Taxaceae), proved to be useful in …
What are two other names for anticancer drugs?
Anticancer drug, also called antineoplastic drug, any drug that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include alkylating agents, antimetabolites, natural products, and hormones.
Who first synthesized cisplatin?
Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm3, a melting point of 270° C, a log Kow of -2.19 and a water solubility of 2.53 g/L at 25° C (HSDB 2009). Cisplatin was first synthesized by M. Peyrone in 1844 and its chemical structure was first elucidated by Alfred Werner in 1893.
What are Antineoplastics drugs?
Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.
How many anticancer drugs are there?
With advances in anticancer drug discovery and development in the last several decades, more than 100 anticancer drugs have been discovered and approved by the FDA [7, 8]. These drugs can be broadly classified into two basic categories: cytotoxic and targeted agents based on their mechanisms of action [9–11].
What are antimetabolite drugs?
Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid).
How bad is cisplatin?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
What drug is given with cisplatin?
Droperidol 1 mg was given intramuscularly (IM) 15 minutes prior to beginning cisplatin. Repetitive doses of intravenous (IV) metoclopramide, 2 mg/kg in 75 ml 5% dextrose in water over 15 minutes was given 30 minutes prior to, and at 1 1/2, 4 1/2, and 7 1/2 hours after beginning cisplatin chemotherapy.
Are all anticancer drugs cytotoxic?
All the anti-cancer drugs proved to be highly cytotoxic agents to normal cells like lymphocyte cells used in our study which do not come under rapidly dividing cells like bone marrow cells, fetal cells, germ cells, hair follicle cells, intestinal cells, etc.
What is the most successful medicine?
Best selling pharmaceuticals of U.S. Market
| Rank | Drug | 2019 |
|---|---|---|
| 1 | adalimumab | 21.4 |
| 2 | apixaban | 9.9 |
| 3 | etanercept | 8.1 |
| 4 | ustekinumab | 6.6 |